Gen-Probe Reports Financial Results for the Second Quarter of 2010

  • Total Revenues Increase 15%, to $138.6 Million, Driven by Blood Screening, Women's Health and Prodesse Products
  • Company Posts Non-GAAP EPS(1) of $0.52(2), 16% Higher than in the Prior Year Period, and GAAP EPS of $0.57
  • Strong Cash Generation Continues, with $34.4 Million of Free Cash Flow(3) in Quarter

SAN DIEGO, July 29, 2010 /PRNewswire via COMTEX/ -- Gen-Probe Incorporated (Nasdaq: GPRO) today reported financial results for the second quarter of 2010, highlighted by 14% growth in product sales, 15% growth in total revenues, and 16% growth in non-GAAP earnings per share (EPS).

"Gen-Probe's second quarter financial results demonstrate our ability to drive growth and execute on our financial goals in a challenging business environment," said Carl Hull, the Company's president and chief executive officer. "At the same time, we made important progress on four US regulatory filings and three European product launches that we expect to create an important new product cycle over the balance of this year and into 2011."

Key financial results for the second quarter of 2010 were ($ in millions, except EPS):

                             Non-GAAP                      GAAP
                             --------                      ----
                       2010     2009  Change     2010     2009  Change
                       ----     ----             ----     ----  ------
    Product sales    $132.7   $116.8      +14% $132.7   $116.8      +14%
    Total revenues   $138.6   $120.5      +15% $138.6   $120.5      +15%
    Operating profit  $37.2    $27.7      +34%  $34.2    $23.2      +47%
    Net income        $26.0 $23.2(4)      +12%  $28.1 $19.8(4)      +42%
    EPS               $0.52    $0.45      +16%  $0.57    $0.38      +50%



Revenue Detail

Clinical diagnostics sales growth in the second quarter of 2010 was driven by the APTIMA Combo 2(R) assay for detecting Chlamydia and gonorrhea, and Prodesse products, which were not part of Gen-Probe in the prior year period. Compared to the prior year period, foreign exchange fluctuations reduced clinical diagnostics sales by an estimated $0.1 million, or less than 1%.

In the second quarter, blood screening sales increased based on:

  • Higher shipments of PROCLEIX(R) ULTRIO(R) and West Nile virus assays, especially in comparison to lower-than-average ordering in the prior year period.
  • Increased sales of TIGRIS(R) instruments to Novartis, the Company's blood screening collaboration partner.
  • The contractual increase in the share of revenues Gen-Probe receives under its collaboration with Novartis.
  • Foreign exchange fluctuations, which added an estimated $0.5 million, or 1%, to blood screening sales.

Sales of research products and services in the second quarter of 2010 were $3.2 million, compared to $3.6 million in the prior year period, a decrease of 11% that resulted mainly from the divestiture of the BioKits food testing business late in 2009, and foreign exchange fluctuations.

Second quarter product sales were ($ in millions):

                            Three Months Ended
                                 June 30,                    Change
                            ------------------             ------
                              2010       2009        As        Constant
                              ----       ----      Reported  Currency(5)
                                                   --------  -----------
    Clinical
     Diagnostics             $73.9      $67.4           +10%         +10%
    Blood Screening          $55.7      $45.8           +22%         +20%
    Research Products
     and                      $3.2       $3.6           -11%          -8%
    Services                  ----       ----           ---          ---
    --------
    Total Product Sales     $132.7     $116.8           +14%         +13%



Collaborative research revenues in the second quarter of 2010 were $4.1 million, compared to $2.2 million in the prior year period, an increase of 86% that resulted primarily from increased funding from Novartis associated with the development of the fully automated PANTHER(TM) instrument for the blood screening market.

Royalty and license revenues in the second quarter of 2010 were $1.8 million, compared to $1.5 million in the prior year period, an increase of 20%.

Expense Detail

Gross margin on product sales in the second quarter of 2010 was 66.7% on a non-GAAP basis, compared to 67.3% in the prior year period. This decrease resulted mainly from increased sales of low-margin instruments, which are generally a precursor to future assay sales. On a GAAP basis, including $0.1 million of acquisition-related depreciation expense, gross margin on product sales was 66.6% in the second quarter of 2010, compared to 67.2% in the prior year period.

On a GAAP basis, acquisition-related amortization expenses were $2.2 million in the second quarter of 2010, compared to $1.1 million in the prior year period, an increase of 100% that resulted primarily from the October 2009 acquisition of Prodesse and its related intangible assets.

Research and development (R&D) expenses in the second quarter of 2010 were $27.1 million, compared to $26.1 million in the prior year period, an increase of 4% that resulted primarily from expenses associated with the Company's development programs for its PANTHER instrument and PCA3 and trichomonas assays, and from the addition of Prodesse's R&D activities.

Marketing and sales expenses in the second quarter of 2010 were $15.8 million, compared to $14.0 million in the prior year period, an increase of 13% that resulted primarily from European sales force expansion and market development efforts.

General and administrative (G&A) expenses in the second quarter of 2010 were $14.3 million on a non-GAAP basis, compared to $14.6 million in the prior year period, a decrease of 2% that resulted primarily from cost-containment efforts. On a GAAP basis, including transaction-related costs, G&A expenses were $15.0 million in the second quarter of 2010, compared to $17.8 million in the prior year period, a decrease of 16% that resulted mainly from fees associated with the acquisition of Tepnel in the prior year period.

Total other income in the second quarter of 2010 was $2.5 million on a non-GAAP basis, compared to $8.5 million in the prior year period. This significant decrease resulted primarily from lower realized gains from the sale of marketable securities, lower yields on the Company's municipal bond portfolio, and lower investment balances due to share repurchases and the acquisition of Prodesse. On a GAAP basis, including a $4.3 million non-cash gain on a change in the fair value of potential contingent payments, total other income was $6.9 million in the second quarter of 2010.

In the second quarter of 2010, Gen-Probe generated net cash of $41.1 million from operating activities, and spent $6.7 million on property, plant and equipment in the quarter, leading to free cash flow of $34.4 million. The Company repurchased approximately 910,500 shares of its stock in the second quarter for $41.3 million.

Gen-Probe continues to have a strong balance sheet. As of June 30, 2010, the Company had $474.8 million of cash, cash equivalents and marketable securities, and $240.8 million of short-term debt. The Company pays interest on substantially all this debt at a rate 0.6% above the one-month London Interbank Offered Rate (LIBOR), which was recently below 0.4%.

                                Updated 2010 Financial Guidance
                                -------------------------------

                                     Current               Previous
                                     Guidance              Guidance
                                    (non-GAAP)            (non-GAAP)
                                    ----------            ----------
    Total revenues            $545 to $562 million  $545 to $565 million
    Product gross margins                    ~ 68%           68% to 69%
    Acquisition-related
     amortization and                          N/A                   N/A
    transaction expense
    Fair value adjustment of
     acquisition-                              N/A                   N/A
    related contingent
     consideration
    Operating margin                    27% to 28%           27% to 28%
    Tax rate                                 ~ 34%           34% to 35%
    Diluted shares                 ~ 49 million          ~ 50 million
    EPS                             $2.12 to $2.25        $2.12 to $2.25


                                      Current                Previous
                                      Guidance               Guidance
                                       (GAAP)                 (GAAP)
                                       ------                 ------
    Total revenues              $545 to $562 million  $545 to $565 million
    Product gross margins                      ~ 68%           68% to 69%
    Acquisition-related
     amortization and         $10.5 to $11.5 million     $9 to $10 million
    transaction expense
    Fair value adjustment of
     acquisition-                       $5.5 million       ($1 million)
    related contingent
     consideration
    Operating margin                      25% to 26%       24.5% to 25.5%
    Tax rate                                   ~ 35%           34% to 35%
    Diluted shares                  ~ 49 million           ~ 50 million
    EPS                               $2.07 to $2.20        $1.99 to $2.12


Webcast Conference Call

A live webcast of Gen-Probe's second quarter 2010 conference call for investors can be accessed at http://www.gen-probe.com beginning at 4:30 p.m. Eastern Time today. The webcast will be archived for at least 90 days. A telephone replay of the call also will be available for approximately 24 hours. The replay number is 866-457-5716 for domestic callers and 203-369-1294 for international callers.

About Gen-Probe

Gen-Probe Incorporated is a global leader in the development, manufacture and marketing of rapid, accurate and cost-effective molecular diagnostic products and services that are used primarily to diagnose human diseases, screen donated human blood, and ensure transplant compatibility. Gen-Probe has approximately 27 years of expertise in nucleic acid testing (NAT), and received the 2004 National Medal of Technology, America's highest honor for technological innovation, for developing NAT assays for blood screening. Gen-Probe is headquartered in San Diego and employs approximately 1,300 people. For more information, go to www.gen-probe.com.

About Non-GAAP Financial Measures

To supplement Gen-Probe's financial results for the second quarter of 2010 and its updated 2010 financial guidance, in each case presented in accordance with GAAP, Gen-Probe uses the following financial measures defined as non-GAAP by the SEC: non-GAAP net income, non-GAAP gross margin, non-GAAP marketing and sales expenses, non-GAAP G&A expenses, non-GAAP operating margin, non-GAAP income tax rate, and non-GAAP EPS. Gen-Probe's management does not, nor does it suggest that investors should, consider such non-GAAP financial measures in isolation from, or as a substitute for, financial information prepared and presented in accordance with GAAP. Gen-Probe's management believes that these non-GAAP financial measures provide meaningful supplemental information regarding the Company's performance by excluding certain expenses and adjustments that may not be indicative of core business results. Gen-Probe believes that both management and investors benefit from referring to these non-GAAP financial measures in assessing Gen-Probe's performance and when planning, forecasting and analyzing future periods. These non-GAAP financial measures also facilitate management's internal comparisons to Gen-Probe's historical performance and our competitors' operating results. Gen-Probe believes these non-GAAP financial measures are useful to investors in allowing for greater transparency with respect to supplemental information used by management in its financial and operational decision making. Further, our reconciliations of non-GAAP to GAAP operating results, which are included on the attached tables, are presented in the format of consolidated statements of income solely to assist a reader in understanding the impact of the various adjustments to our GAAP operating results, individually and in the aggregate, and are not intended to place any undue prominence on our non-GAAP operating results.

Trademarks

APTIMA, APTIMA COMBO 2, TIGRIS and PANTHER are trademarks of Gen-Probe. All other trademarks are the property of their owners.

Caution Regarding Forward-Looking Statements

Any statements in this news release about our expectations, beliefs, plans, objectives, assumptions or future events or performance, including those under the heading "Updated 2010 Financial Guidance," are not historical facts and are forward-looking statements. These statements are often, but not always, made through the use of words or phrases such as believe, will, expect, anticipate, estimate, intend, plan and would. For example, statements concerning Gen-Probe's financial condition, possible or expected results of operations, regulatory approvals, future milestones, growth opportunities, and plans of management are all forward-looking statements. Forward-looking statements are not guarantees of performance. They involve known and unknown risks, uncertainties and assumptions that may cause actual results, levels of activity, performance or achievements to differ materially from those expressed or implied. Some of these risks, uncertainties and assumptions include but are not limited to: (i) the risk that we may not achieve our expected 2010 financial targets, (ii) the risk that we may not integrate acquisitions, such as Tepnel and Prodesse, successfully, (iii) the possibility that the market for the sale of our new products, such as our PANTHER instrument system and PROGENSA PCA3, APTIMA HPV and APTIMA trichomonas assays, may not develop as expected, (iv) the enhancement of existing products and the development of new products may not proceed as planned, (v) the risk that investigational products, including those now in US clinical trials, may not be approved by regulatory authorities or become commercially available in the time frame we anticipate, or at all, (vi) the risk that we may not be able to compete effectively, (vii) the risk that we may not be able to maintain our current corporate collaborations and enter into new corporate collaborations or customer contracts, (viii) our dependence on Novartis and other third parties for the distribution of some of our products, (ix) our dependence on a small number of customers, contract manufacturers and single source suppliers of raw materials, (x) changes in third-party reimbursement policies regarding our products could adversely affect sales, (xi) changes in government regulation or tax policy affecting our diagnostic products could harm our sales, increase our development costs or increase our taxes, (xii) the risk that our intellectual property may be infringed by third parties or invalidated, and (xiii) our involvement in patent and other intellectual property and commercial litigation could be expensive and could divert management's attention. This list includes some, but not all, of the factors that could affect our ability to achieve results described in any forward-looking statements. For additional information about risks and uncertainties we face and a discussion of our financial statements and footnotes, see documents we file with the SEC, including our most recent annual report on Form 10-K and all subsequent periodic reports. We assume no obligation and expressly disclaim any duty to update forward-looking statements to reflect events or circumstances after the date of this news release or to reflect the occurrence of subsequent events.

(1) In this press release, all per share amounts are calculated on a fully diluted basis. Some totals may not foot due to rounding. Certain prior year amounts have been reclassified to conform to the current year presentation.

(2) Non-GAAP EPS for the second quarter of 2010 excludes $3.0 million of transaction-related operating expense, and a $4.3 million gain on contingent consideration associated with the Prodesse acquisition.

(3) Cash from operations less purchases of property, plant and equipment.

(4) In the prior year period, net income benefited from $10.1 million of investment and interest income, compared to $3.3 million in the second quarter of 2010.

(5) In this press release, estimates of "constant currency" growth exclude currency fluctuations associated with revenues from Prodesse, which was not part of Gen-Probe in the second quarter of 2009.

                                 Gen-Probe Incorporated
                           Consolidated Balance Sheets - GAAP
                     (In thousands, except share and per share data)

                                                    June 30,    Dec. 31,
                                                          2010        2009
                                                          ----        ----
                                                  (unaudited)
    Assets
    Current assets:
      Cash and cash equivalents, including
       restricted cash of $15 and $17 at June 30,
       2010                                           $174,922     $82,616
    and December 31, 2009, respectively
      Marketable securities                            288,718     402,990
      Trade accounts receivable, net of allowance
       for doubtful accounts of $339 and $516 at        55,415      55,305
    June 30, 2010 and December 31, 2009,
     respectively
      Accounts receivable - other                        5,776       4,707
      Inventories                                       57,754      61,071
      Deferred income tax                               14,466      13,959
      Prepaid income tax                                 1,433       7,317
      Prepaid expenses                                  12,794      14,747
      Other current assets                               3,758       4,708
                                                         -----       -----
    Total current assets                               615,036     647,420

    Marketable securities, net of current
     portion                                            11,130      15,472
    Property, plant and equipment, net                 157,782     157,437
    Capitalized software, net                           12,711      12,560
    Goodwill                                           121,942     122,680
    Purchased intangibles, net                         102,813     108,015
    License, manufacturing access fees and other
     assets, net                                       113,001      64,601
    Total assets                                    $1,134,415  $1,128,185
                                                    ==========  ==========

    Liabilities and stockholders' equity
    Current liabilities:
      Accounts payable                                 $18,850     $26,750
      Accrued salaries and employee benefits            22,594      27,093
      Other accrued expenses                            19,561      18,460
      Income tax payable                                 1,372           -
      Short-term borrowings                            240,796     240,841
      Deferred revenue                                   2,616       3,527
                                                         -----       -----
    Total current liabilities                          305,789     316,671

    Non-current income tax payable                       6,287       5,958
    Deferred income tax                                 21,899      23,220
    Deferred revenue, net of current portion             1,532       1,978
    Other long-term liabilities                          3,944      13,183

    Commitments and contingencies

    Stockholders' equity:
    Preferred stock, $0.0001 par value per
     share; 20,000,000 shares authorized, none               -           -
    issued and outstanding
    Common stock, $0.0001 par value per share;
     200,000,000 shares authorized,                          5           5
    48,710,930 and 49,143,798 shares issued and
     outstanding at June 30, 2010 and
    December 31, 2009, respectively
    Additional paid-in capital                         223,452     242,615
    Accumulated other comprehensive income
     (loss)                                               (733)      4,616
    Retained earnings                                  572,240     519,939
    Total stockholders' equity                         794,964     767,175
                                                       -------     -------
    Total liabilities and stockholders' equity      $1,134,415  $1,128,185
                                                    ==========  ==========



                                  Gen-Probe Incorporated
                         Consolidated Statements of Income - GAAP
                           (In thousands, except per share data)
                                        (unaudited)

                                Three Months Ended         Six Months Ended
                                     June 30,                  June 30,
                                   2010          2009      2010          2009
                                   ----          ----      ----          ----
    Revenues:
      Product sales            $132,734      $116,816  $263,303      $229,338
      Collaborative research
       revenue                    4,141         2,187     7,405         3,862
      Royalty and license
       revenue                    1,774         1,542     3,360         3,528
                                  -----         -----     -----         -----
    Total revenues              138,649       120,545   274,068       236,728

    Operating expenses:
      Cost of product sales
       (excluding acquisition-   44,311        38,280    86,972        71,594
    related intangible
     amortization)
      Acquisition-related
       intangible amortization    2,199         1,114     4,415         1,114
      Research and development   27,104        26,069    56,785        51,067
      Marketing and sales        15,824        14,015    30,605        25,070
      General and
       administrative            15,018        17,823    29,697        31,670
                                 ------        ------    ------        ------
    Total operating expenses    104,456        97,301   208,474       180,515
                                -------        ------   -------       -------
    Income from operations       34,193        23,244    65,594        56,213
    Other income/(expense):
      Investment and interest
       income                     3,269        10,122     7,167        15,004
      Interest expense             (549)         (726)   (1,095)         (877)
      Gain on contingent
       consideration              4,337             -     6,082             -
      Other expense, net           (190)         (895)     (349)       (1,037)
                                   ----          ----      ----        ------
    Total other income, net       6,867         8,501    11,805        13,090
                                  -----         -----    ------        ------
    Income before income tax     41,060        31,745    77,399        69,303

    Income tax expense           12,950        11,930    25,096        23,741
    Net income                  $28,110       $19,815   $52,303       $45,562
                                =======       =======   =======       =======

    Net income per share:
      Basic                       $0.57         $0.39     $1.06         $0.88
                                  =====         =====     =====         =====
      Diluted                     $0.57         $0.38     $1.05         $0.87
                                  =====         =====     =====         =====

    Weighted average shares
     outstanding:
      Basic                      48,902        51,034    49,066        51,600
                                 ======        ======    ======        ======
      Diluted                    49,366        51,739    49,549        52,291
                                 ======        ======    ======        ======



                                       Gen-Probe Incorporated
                                  Consolidated Statements of Income
                                (In thousands, except per share data)
                                             (unaudited)

                                         Three Months Ended
                                            June 30, 2010
                                 Non-GAAP   Adjustments     GAAP
                                 --------   -----------     ----
    Revenues:
      Product sales               $132,734           $-   $132,734
      Collaborative research
       revenue                       4,141            -      4,141
      Royalty and license
       revenue                       1,774            -      1,774
                                     -----          ---      -----
    Total revenues                 138,649            -    138,649

    Operating expenses:
      Cost of product sales
       (excluding                   44,221           90     44,311
    acquisition-related
     intangible
    amortization)
      Acquisition-related
       intangible                        -        2,199      2,199
    amortization
      Research and development      27,104            -     27,104
      Marketing and sales           15,824            -     15,824
      General and
       administrative               14,349          669     15,018
                                    ------          ---     ------
    Total operating expenses       101,498        2,958    104,456
                                   -------        -----    -------
    Income from operations          37,151       (2,958)    34,193
    Other income/(expense):
      Investment and interest
       income                        3,269            -      3,269
      Interest expense                (549)           -       (549)
      Gain on contingent
       consideration                     -        4,337      4,337
      Other expense, net              (190)           -       (190)
                                      ----          ---       ----
    Total other income, net          2,530        4,337      6,867
                                     -----        -----      -----
    Income before income tax        39,681        1,379     41,060

    Income tax expense              13,720         (770)    12,950
    Net income                     $25,961       $2,149    $28,110
                                   =======       ======    =======

    Net income per share:
      Basic                          $0.53        $0.04      $0.57
                                     =====        =====      =====
      Diluted                        $0.52        $0.05      $0.57
                                     =====        =====      =====

    Weighted average shares
     outstanding:
      Basic                         48,902            -     48,902
                                    ======          ===     ======
      Diluted                       49,366            -     49,366
                                    ======          ===     ======


                                          Three Months Ended
                                            June 30, 2009
                                 Non-GAAP   Adjustments     GAAP
                                 --------   -----------     ----
    Revenues:
      Product sales               $116,816           $-    $116,816
      Collaborative research
       revenue                       2,187            -       2,187
      Royalty and license
       revenue                       1,542            -       1,542
                                     -----          ---       -----
    Total revenues                 120,545            -     120,545

    Operating expenses:
      Cost of product sales
       (excluding                   38,190           90      38,280
    acquisition-related
     intangible
    amortization)
      Acquisition-related
       intangible                        -        1,114       1,114
    amortization
      Research and development      26,069            -      26,069
      Marketing and sales           14,015            -      14,015
      General and
       administrative               14,619        3,204      17,823
                                    ------        -----      ------
    Total operating expenses        92,893        4,408      97,301
                                    ------        -----      ------
    Income from operations          27,652       (4,408)     23,244
    Other income/(expense):
      Investment and interest
       income                       10,122            -      10,122
      Interest expense                (726)           -        (726)
      Gain on contingent
       consideration                     -            -           -
      Other expense, net              (895)           -        (895)
                                      ----          ---        ----
    Total other income, net          8,501            -       8,501
                                     -----          ---       -----
    Income before income tax        36,153       (4,408)     31,745

    Income tax expense              12,951       (1,021)     11,930
    Net income                     $23,202      $(3,387)    $19,815
                                   =======      =======     =======

    Net income per share:
      Basic                          $0.45       $(0.06)      $0.39
                                     =====       ======       =====
      Diluted                        $0.45       $(0.07)      $0.38
                                     =====       ======       =====

    Weighted average shares
     outstanding:
      Basic                         51,034            -      51,034
                                    ======          ===      ======
      Diluted                       51,739            -      51,739
                                    ======          ===      ======


                                        Gen-Probe Incorporated
                                   Consolidated Statements of Income
                                 (In thousands, except per share data)
                                              (unaudited)

                                              Six Months Ended
                                                June 30, 2010
                                     Non-GAAP    Adjustments     GAAP
                                     --------    -----------     ----
    Revenues:
      Product sales                   $263,303            $-    $263,303
      Collaborative research
       revenue                           7,405             -       7,405
      Royalty and license revenue        3,360             -       3,360
                                         -----           ---       -----
    Total revenues                     274,068             -     274,068

    Operating expenses:
      Cost of product sales
       (excluding                       86,791           181      86,972
    acquisition-related
     intangible
    amortization)
      Acquisition-related
       intangible amortization               -         4,415       4,415
        Research and development        56,785             -      56,785
        Marketing and sales             30,605             -      30,605
        General and administrative      29,001           696      29,697
                                        ------           ---      ------
    Total operating expenses           203,182         5,292     208,474
                                       -------         -----     -------
    Income from operations              70,886        (5,292)     65,594
    Other income/(expense):
      Investment and interest
       income                            7,167             -       7,167
      Interest expense                  (1,095)            -      (1,095)
      Gain on contingent
       consideration                         -         6,082       6,082
      Other expense, net                  (349)            -        (349)
                                          ----           ---        ----
    Total other income, net              5,723         6,082      11,805
                                         -----         -----      ------
    Income before income tax            76,609           790      77,399

    Income tax expense                  26,677        (1,581)     25,096
    Net income                         $49,932        $2,371     $52,303
                                       =======        ======     =======

    Net income per share:
      Basic                              $1.01         $0.05       $1.06
                                         =====         =====       =====
      Diluted                            $1.00         $0.05       $1.05
                                         =====         =====       =====

    Weighted average shares
     outstanding:
      Basic                             49,066             -      49,066
                                        ======           ===      ======
      Diluted                           49,549             -      49,549
                                        ======           ===      ======


                                              Six Months Ended
                                                June 30, 2009
                                     Non-GAAP    Adjustments     GAAP
                                     --------    -----------     ----
    Revenues:
      Product sales                   $229,338            $-    $229,338
      Collaborative research
       revenue                           3,862             -       3,862
      Royalty and license revenue        3,528             -       3,528
                                         -----           ---       -----
    Total revenues                     236,728             -     236,728

    Operating expenses:
      Cost of product sales
       (excluding                       71,504            90      71,594
    acquisition-related
     intangible
    amortization)
      Acquisition-related
       intangible amortization               -         1,114       1,114
        Research and development        51,067             -      51,067
        Marketing and sales             25,070             -      25,070
        General and administrative      26,864         4,806      31,670
                                        ------         -----      ------
    Total operating expenses           174,505         6,010     180,515
                                       -------         -----     -------
    Income from operations              62,223        (6,010)     56,213
    Other income/(expense):
      Investment and interest
       income                           15,004             -      15,004
      Interest expense                    (877)            -        (877)
      Gain on contingent
       consideration                         -             -           -
      Other expense, net                (1,037)            -      (1,037)
                                        ------           ---      ------
    Total other income, net             13,090             -      13,090
                                        ------           ---      ------
    Income before income tax            75,313        (6,010)     69,303

    Income tax expense                  25,069        (1,328)     23,741
    Net income                         $50,244       $(4,682)    $45,562
                                       =======       =======     =======

    Net income per share:
      Basic                              $0.97        $(0.09)      $0.88
                                         =====        ======       =====
      Diluted                            $0.96        $(0.09)      $0.87
                                         =====        ======       =====

    Weighted average shares
     outstanding:
      Basic                             51,600             -      51,600
                                        ======           ===      ======
      Diluted                           52,291             -      52,291
                                        ======           ===      ======


                                     Gen-Probe Incorporated
                          Consolidated Statements of Cash Flows - GAAP
                                         (In thousands)
                                          (unaudited)

                                                    Six Months Ended
                                                        June 30,
                                                        --------
                                                      2010          2009
                                                      ----          ----
    Operating activities:
      Net income                                   $52,303       $45,562
      Adjustments to reconcile net income to net
       cash provided by operating activities:
       Depreciation and amortization                22,628        19,463
       Amortization of premiums on investments,
        net of accretion of discounts                4,523         2,720
       Stock-based compensation                     12,338        11,405
       Stock-based compensation income tax
        benefits                                     2,096           310
       Excess tax benefit from employee stock-
        based compensation                            (919)         (702)
       Deferred revenue                             (1,241)         (255)
       Deferred income tax                          (1,930)       (1,134)
       Gain on contingent consideration             (6,082)            -
       Loss on disposal of property and equipment      143            69
       Changes in assets and liabilities:
         Trade and other accounts receivable        (1,494)        1,372
         Inventories                                 2,998         3,890
         Prepaid expenses                            1,907         2,835
         Other current assets                          918         2,081
         Other long-term assets                        390        (2,486)
         Accounts payable                           (7,082)       (2,218)
         Accrued salaries and employee benefits     (4,336)       (7,272)
         Other accrued expenses                     (1,086)        1,337
         Income tax payable                          6,434        (3,704)
         Other long-term liabilities                  (684)          335
    Net cash provided by operating activities       81,824        73,608
                                                    ------        ------

    Investing activities:
    Proceeds from sales and maturities of
     marketable securities                         279,853       293,504
    Purchases of marketable securities            (166,290)     (189,091)
    Purchases of property, plant and equipment     (14,567)      (14,666)
    Purchases of capitalized software               (1,457)         (288)
    Purchases of intangible assets, including
     licenses and manufacturing access fees         (1,365)         (811)
    Net cash paid for business combinations              -      (123,816)
    Cash paid for investment in Pacific
     Biosciences                                   (50,000)            -
    Cash paid for investment in DiagnoCure and
     related license fees                             (500)       (5,250)
    Other                                           (1,967)         (289)
    Net cash provided by (used in) investing
     activities                                     43,707       (40,707)
                                                    ------       -------

    Financing activities:
    Repurchase and retirement of common stock      (52,299)     (105,577)
    Proceeds from issuance of common stock and
     ESPP                                           20,062         3,777
    Repurchase and retirement of restricted
     stock for payment of taxes                        (43)          (38)
    Excess tax benefit from stock-based
     compensation                                      919           702
    Borrowings under credit facility                     -       238,450
    Net cash (used in) provided by financing
     activities                                    (31,361)      137,314
                                                   -------       -------
    Effect of exchange rate changes on cash and
     cash equivalents                               (1,864)        1,918
                                                    ------         -----
    Net increase in cash and cash equivalents       92,306       172,133
    Cash and cash equivalents at the beginning
     of period                                      82,616        60,122
    Cash and cash equivalents at the end of
     period                                       $174,922      $232,255
                                                  ========      ========



    Contact:

    Michael Watts
    Vice president, investor relations and corporate communications
    858-410-8673


SOURCE Gen-Probe Incorporated



Gen-Probe Incorporated
10210 Genetic Center Drive
San Diego, CA 92121

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