Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2005
- Fourth Quarter Earnings Per Share Increase to $0.32, 39% Growth From Prior Year - - Total Revenues of $88.0 Million and Product Sales of $78.0 Million Both Establish New Quarterly Records -

SAN DIEGO, Feb 15, 2006 /PRNewswire-FirstCall via COMTEX News Network/ -- Gen-Probe Incorporated (Nasdaq: GPRO) today reported strong financial results for the fourth quarter and full year ended December 31, 2005. Net income for the fourth quarter of 2005 was $16.8 million ($0.32 per share), compared to net income of $12.0 million ($0.23 per share), in the prior year period, an increase of 39% per share. All per share amounts are calculated on a fully diluted basis.

Total revenues established a new record of $88.0 million in the fourth quarter of 2005, compared to $68.5 million in the prior year period, an increase of 28%. Product sales also hit an all-time high of $78.0 million in the fourth quarter of 2005, compared to $58.5 million in the prior year period, an increase of 33%.

For the full year 2005, net income was $60.1 million ($1.15 per share), compared to net income of $54.6 million ($1.06 per share) in 2004, an increase of 8% per share. Total revenues in 2005 were $306.0 million, compared to $269.7 million in 2004, an increase of 13%. As previously disclosed, in 2004 Gen-Probe earned royalty and license revenue from Tosoh and a contract milestone from Chiron that together added $13.5 million to total revenues, and $0.17 to earnings per share. Product sales in 2005 were $271.7 million, compared to $222.6 million in 2004, an increase of 22%.

"Our strong fourth quarter results capped off an outstanding year for Gen-Probe," said Henry L. Nordhoff, the Company's chairman, president and chief executive officer. "Both our clinical diagnostics and blood screening businesses grew solidly in the fourth quarter and established new records, driven by continued strength across our major product lines."

Detailed Results

Compared to the prior year period, Gen-Probe's sales growth in the fourth quarter of 2005 was led by the APTIMA COMBO 2(R) and PROCLEIX(R) ULTRIO(R) assays, and by the TIGRIS(R) system for blood screening outside the United States. Gen-Probe's blood screening products are marketed worldwide by Chiron.

Sales of the APTIMA COMBO 2 assay, Gen-Probe's amplified nucleic acid test (NAT) for simultaneously detecting and identifying Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC), continued to grow strongly in the fourth quarter. This sales growth was driven by market share gains on both the Company's semi-automated instrument platform and on the high-throughput, fully automated TIGRIS system. Revenue from the PACE(R) product line, the Company's non-amplified tests for the same microorganisms, declined in the fourth quarter compared to the prior year period, in line with Gen-Probe's expectations.

In blood screening, product sales benefited from continued growth of the PROCLEIX ULTRIO assay in Europe. The PROCLEIX ULTRIO assay simultaneously detects HIV-1, hepatitis C virus and hepatitis B virus in donated blood. Blood screening sales in the fourth quarter also benefited from sales of TIGRIS instruments and spare parts to Chiron, which totaled $4.1 million, and from the recognition of approximately $3.6 million of previously deferred domestic blood screening revenue. This revenue recognition, which was greater than expected, resulted from Chiron establishing its own warehouse for U.S. blood screening inventory.

Product sales for the fourth quarter and full year were, in millions:

                         Three Months Ended Dec. 31,    Year Ended Dec. 31,
                           2005    2004   Increase    2005    2004   Increase
    Clinical diagnostics  $37.3   $32.6      14%     $141.7  $127.0     12%
    Blood screening       $40.7   $25.9      57%     $130.0   $95.6     36%
    Total product sales   $78.0   $58.5      33%     $271.7  $222.6     22%

Collaborative research revenues for the fourth quarter of 2005 were $6.5 million, compared to $7.9 million in the prior year period, a decrease of 18% that resulted primarily from lower reimbursement from Chiron of blood screening development expenses. For the full year 2005, collaborative research revenues were $25.8 million, compared to $27.1 million in 2004, a decrease of 5% that resulted primarily from reduced grant funding from the National Institutes of Health.

Royalty and license revenues for the fourth quarter of 2005 were $3.5 million, compared to $2.2 million in the prior year period, an increase of 59%. This increase resulted primarily from license revenue earned from bioMerieux. For the full year 2005, royalty and license revenues were $8.5 million, compared to $20.0 million in 2004. As previously discussed, royalty and license revenues were unusually high in 2004 due to revenues earned through certain milestone payments associated with the Company's agreements with Chiron and Tosoh.

Gross margin as a percentage of product sales was 66% in the fourth quarter of 2005, compared to 70% in the prior year period. This decrease resulted primarily from sales of TIGRIS instruments and spare parts to Chiron for blood screening. These sales occur contractually at close to cost, and are expected to be a precursor to higher margin sales of the PROCLEIX ULTRIO assay. Gross margin percentage also was negatively affected by the recognition of deferred revenue associated with Chiron's decision to open a new warehouse for blood screening products, since Gen-Probe records this revenue at a contractual transfer price that results in a low margin. For the full year 2005, gross margin on product sales was 69%, compared to 73% in 2004. The decrease in product gross margin percentage was due to the factors described above, and to the amortization of capitalized software costs related to the TIGRIS system.

Research and development (R&D) expenses were $18.2 million in the fourth quarter of 2005, compared to $18.5 million in the prior year period, a decrease of 2%. In the prior year period, R&D expenses included $1 million paid to AdnaGen AG for access to its immunocapture technology. For the full year 2005, R&D expenses were $71.8 million, compared to $68.5 million in 2004, an increase of 5% that resulted primarily from costs associated with the Company's prostate cancer and human papillomavirus (HPV) programs, and from expenses related to the PROCLEIX ULTRIO and West Nile Virus (WNV) assays for blood screening.

Marketing and sales expenses were $8.8 million in the fourth quarter of 2005, compared to $7.2 million in the prior year period, an increase of 22%. For the full year 2005, marketing and sales expenses were $31.1 million, compared to $27.2 million in 2004, an increase of 14%. These increases resulted primarily from the costs of supporting commercialization of the TIGRIS system and investing in new market opportunities.

General and administrative (G&A) expenses were $9.3 million in the fourth quarter of 2005, compared to $7.8 million in the prior year period, an increase of 19% that resulted primarily from higher legal expenses associated with the Company's patent infringement suits against Bayer. For the full year 2005, G&A expenses were $32.1 million, compared to $31.6 million in 2004, an increase of 2%.

Gen-Probe continues to have a strong balance sheet. As of December 31, 2005, the Company had $220.3 million of cash, cash equivalents and short-term investments, and no debt. The Company's cash balance was essentially flat in the fourth quarter, as cash generated from operations was largely offset by $15.5 million of capital spending, primarily to expand the Company's headquarters campus. Gen-Probe generated net cash of $85.9 million from its operating activities in 2005, representing 28% of total revenues.

Recent Events

* PROCLEIX WNV Assay. In early December, the U.S. Food and Drug Administration (FDA) granted marketing approval to use the Company's PROCLEIX WNV assay to screen donated human blood on the enhanced semi-automated instrument system (eSAS). Based on the early approval of the WNV assay on the eSAS, as well as discussions with the FDA and customers, Gen-Probe has accelerated the necessary regulatory filings for use of the WNV assay on the Company's fully automated, high-throughput TIGRIS system. Gen-Probe expects to file a 510(k) application for use of the WNV assay on the TIGRIS system by the end of April 2006. Gen-Probe expects those customers currently using the TIGRIS system to test for WNV under an IND to pay an increased cost recovery price until the TIGRIS system is approved.

* PROCLEIX ULTRIO Assay. Gen-Probe remains on track to respond by the end of March to questions posed by the FDA in the agency's complete review letter for the PROCLEIX ULTRIO assay on the eSAS. Gen-Probe's response will be in the form of an amended Biologics License Application (BLA). If this amended BLA is approved, the Company plans to submit a supplemental BLA containing data describing the use of the PROCLEIX ULTRIO assay on the TIGRIS system. In addition, following the anticipated clearance of the TIGRIS system to run the WNV assay, the Company intends to file another 510(k) application for use of the PROCLEIX ULTRIO assay on the TIGRIS system. Based on the estimated regulatory review times associated with these filings, Gen-Probe believes that approval of the PROCLEIX ULTRIO assay on the TIGRIS system is more likely in 2007 than 2006.

* National Medal of Technology. President George W. Bush named Gen-Probe a 2004 National Medal of Technology Laureate in recognition of the Company's pioneering work in developing innovative nucleic acid tests to safeguard the nation's donated blood supply from viruses such as HIV-1 and the hepatitis C virus. The Medal is the nation's highest honor for technological innovation. Gen-Probe CEO Henry Nordhoff received the award from President Bush at a White House ceremony on February 13.

* BioMerieux Option Exercise. BioMerieux exercised a second option to develop diagnostic products for certain undisclosed disease targets using Gen-Probe's patented ribosomal RNA technologies, pursuant to terms of a 2004 agreement, and paid Gen-Probe a $2.1 million license fee. BioMerieux retains an option to develop products for other disease targets by paying Gen-Probe up to an additional $0.9 million by the end of 2006. BioMerieux exercised its first option in January of 2005 and paid Gen-Probe a $4.5 million license fee, $1.9 of which was recorded as license revenue in the first quarter of 2005. Based on the two option exercises, Gen-Probe recorded another $1.9 million of license revenue in the fourth quarter of 2005, since accounting rules require that revenue be recognized based on the total number of targets eventually selected.

* Changes to Board of Directors. In February 2006, Gerald D. Laubach, Ph.D., informed the Company that he intends to retire from the Gen-Probe board of directors and not stand for re-election at the 2006 annual meeting of stockholders, which is scheduled for May 17. "Gerry has made tremendous contributions to our board since 2002 and his wise counsel will be sorely missed," Nordhoff said. "We wish him all the best in retirement." Separately, John W. Brown joined the board in December. Mr. Brown is chairman of the board of Stryker Corporation, a worldwide leader in orthopedic medical devices. He has served as chairman of the board of Stryker since 1981. He was president and chief executive officer of the company from 1977 to 2003, and chief executive officer from 2003 to 2004.

2006 Financial Guidance

"We expect 2006 to be another year of solid product sales growth and high profitability for Gen-Probe," said Herm Rosenman, the Company's vice president of finance and chief financial officer. "We expect growth to be led by continued market share gains of the APTIMA Combo 2 assay, by ongoing international expansion of the PROCLEIX ULTRIO assay on the TIGRIS system, and by the PROCLEIX WNV assay in the United States. We anticipate that this strong top-line performance will enable us to invest appropriately in attractive R&D projects to drive our future growth, while still delivering exceptional net profit margins."

Gen-Probe's non-GAAP 2006 guidance for gross margins, R&D expenses, marketing and sales expenses, G&A expenses, effective income tax rate and EPS is computed without the effect of adopting SFAS No. 123(R) and is reconciled to the corresponding GAAP measure in the bullets and table below and discussed in the section titled "About Non-GAAP Financial Measures." In accordance with SEC regulations and SFAS No. 123(R), Gen-Probe will begin expensing stock options and related equity compensation beginning with first quarter 2006 results.

For the full year 2006, Gen-Probe expects:

* Total revenues of $325 million to $335 million, including product sales growth of 14% to 16%, in line with the Company's long-term growth goals. The Company's 2006 revenue guidance does not include a $10 million milestone that will be earned from Chiron upon U.S. approval of the PROCLEIX ULTRIO assay on the TIGRIS system. As previously discussed, based on the estimated regulatory review times associated with various filings, Gen-Probe believes this approval is more likely in 2007 than 2006.

* Product gross margins to improve to approximately 70% to 72% of product sales on a non-GAAP basis. On a GAAP basis, product gross margins are expected to range from 68% to 70% of product sales. This improvement over 2005 is expected to result in part from the leverage inherent in rising manufacturing volumes. However, the margin improvement is expected to be tempered by sales of TIGRIS instruments to Chiron for blood screening customers, which contractually are made at cost. Based primarily on strong demand for TIGRIS instruments among blood screening customers outside the United States, Gen-Probe expects to roughly double its installed base of TIGRIS instruments worldwide in 2006.

* R&D expenses approximating 23% to 24% of total revenues on a non-GAAP basis. On a GAAP basis, R&D expenses are expected to range from 26% to 27% of total revenues. Key R&D priorities for 2006 include filing U.S. regulatory applications for the PROCLEIX ULTRIO assay and TIGRIS instrument for blood screening, continuing the Company's oncology programs, pursuing the industrial collaborations with Millipore and General Electric, and supporting the TIGRIS system and next-generation instrument platforms. The Company believes these projects represent significant new market opportunities, and intends to continue investing heavily in them, while at the same time maintaining exceptional profit margins.

* Marketing and sales expenses approximating 9% to 10% of total revenues on a non-GAAP basis. On a GAAP basis, marketing and sales expenses are expected to range from 10% to 11% of total revenues. In absolute dollar terms, marketing and sales expenses are expected to increase from 2005 levels based on the costs associated with assessing and developing new molecular diagnostic markets such as prostate cancer.

* G&A expenses approximating 9% to 10% of total revenues on a non-GAAP basis. On a GAAP basis, G&A expenses are expected to range from 11% to 12% of total revenues. In absolute dollar terms, G&A expenses are expected to increase from 2005 levels based on legal expenses associated with the Company's two patent infringement lawsuits against Bayer.

* EPS of between $1.30 and $1.35 on a fully diluted, non-GAAP basis. This EPS estimate excludes approximately $0.11 of EPS that would result from earning the milestone associated with FDA approval of the PROCLEIX ULTRIO assay on the TIGRIS system. As previously discussed, based on the regulatory review times associated with various filings, Gen-Probe believes this approval is more likely in 2007 than 2006. On a GAAP basis, EPS are expected to range from $0.95 to $1.05. This estimate includes aggregate stock-based compensation expense of between ($0.30) and ($0.35) per share. Gen-Probe's EPS guidance is based on a fully diluted share count of 53.5 million for the year and a tax rate of approximately 37% on a non-GAAP basis, and 36% on a GAAP basis.

The following table provides a reconciliation between Gen-Probe's GAAP and non-GAAP guidance. The percentages shown are of total revenues.

GAAP       Estimated Effects of        Non-GAAP
                         Guidance      SFAS No. 123(R)  (a)       Guidance
    Product Gross
     Margin             68% to 70%        Approx. 2%    (b)       70% to 72%
    R&D Expenses        26% to 27%        Approx. 3%    (c)       23% to 24%
    Marketing and
     Sales Expenses     10% to 11%        Approx. 1%    (c)        9% to 10%
    G&A Expenses        11% to 12%        Approx. 2%    (c)        9% to 10%
    Effective Income
     Tax Rate          Approx. 36%        Approx. 1%    (d)      Approx. 37%
    Diluted EPS     $0.95 to $1.05    $0.30 to $0.35    (e)   $1.30 to $1.35

    (a) These estimated effects reconcile the Company's 2006 GAAP financial
        guidance ranges to the Company's non-GAAP financial guidance ranges.
        The reconciling item represents the estimated impact of SFAS No.
        123(R), which includes non-cash stock compensation awards, including
        stock options and employee stock purchase plan shares.
    (b) Reflects the estimated effect of SFAS No. 123(R) on the Company's
        product sales gross margin percentage guidance range.
    (c) Reflects the estimated effect of SFAS No. 123(R) on the Company's
        expense line guidance as a percentage of total revenues for 2006.
    (d) Amount reflects the estimated tax effect related to the adoption of
        SFAS No. 123(R).
    (e) Amount reflects the estimated effect on EPS for the adoption of SFAS
        No. 123(R) to reconcile the Company non-GAAP EPS guidance range to the
        estimated GAAP EPS guidance range.



    About Non-GAAP Financial Measures

To supplement Gen-Probe's 2006 financial guidance presented in accordance with GAAP, Gen-Probe uses the following financial measures defined as non-GAAP by the SEC: non-GAAP product gross margin, non-GAAP R&D expenses, non-GAAP marketing and sales expenses, non-GAAP G&A expenses, non-GAAP effective income tax rate, and non-GAAP diluted EPS. Gen-Probe's management does not itself, nor does it suggest that investors should, consider such non-GAAP financial measures in isolation from, or as a substitute for, financial information prepared and presented in accordance with GAAP. Gen-Probe's management believes that these non-GAAP financial measures provide meaningful supplemental information regarding the Company's performance by excluding certain expenses that may not be indicative of core business results. Gen-Probe believes that both management and investors benefit from referring to these non-GAAP financial measures in assessing Gen-Probe's performance and when planning, forecasting and analyzing future periods. These non-GAAP financial measures also facilitate management's internal comparisons to Gen-Probe's historical performance and our competitors' operating results. Gen-Probe believes these non-GAAP financial measures are useful to investors in allowing for greater transparency with respect to supplemental information used by management in its financial and operational decision making.

Webcast Conference Call

A live webcast of Gen-Probe's fourth quarter 2005 conference call for investors can be accessed at http://www.gen-probe.com beginning at 4:30 p.m. Eastern Time on February 15, 2006. The webcast will be archived for at least 90 days. A telephone replay of the call also will be available for approximately 24 hours. The replay number is (888) 566-0043 for domestic callers and (402) 998-1629 for international callers.

About Gen-Probe

Gen-Probe Incorporated is a global leader in the development, manufacture and marketing of rapid, accurate and cost-effective nucleic acid tests (NATs) that are used primarily to diagnose human diseases and screen donated human blood. Gen-Probe has more than 20 years of NAT expertise, and received the 2004 National Medal of Technology, America's highest honor for technological innovation, for developing NAT assays for blood screening. Gen-Probe is headquartered in San Diego and employs approximately 900 people. For more information, go to www.gen-probe.com.

TIGRIS, APTIMA, APTIMA COMBO 2 and PACE are trademarks of Gen-Probe Incorporated. ULTRIO and PROCLEIX are trademarks of Chiron Corporation.

Caution Regarding Forward-Looking Statements

Any statements in this press release about our expectations, beliefs, plans, objectives, assumptions or future events or performance, including those under the heading "2006 Financial Guidance," are not historical facts and are forward-looking statements. These statements are often, but not always, made through the use of words or phrases such as believe, will, expect, anticipate, estimate, intend, plan and would. For example, statements concerning Gen-Probe's financial condition, possible or expected results of operations, regulatory approvals, future milestone payments, growth opportunities, and plans and objectives of management are all forward-looking statements. Forward-looking statements are not guarantees of performance. They involve known and unknown risks, uncertainties and assumptions that may cause actual results, levels of activity, performance or achievements to differ materially from those expressed or implied by any forward-looking statement. Some of these risks, uncertainties and assumptions include but are not limited to: (i) the risk that we may not achieve our expected 2006 growth, revenue, earnings or other financial targets, (ii) the risk that Bayer may successfully appeal the arbitration decision that favored us, (iii) the risk that we may not earn or receive milestone payments from our collaborators, including Chiron, (iv) the possibility that the market for the sale of our new products, such as our TIGRIS system, APTIMA Combo 2 assay and PROCLEIX ULTRIO assay, may not develop as expected, (v) the enhancement of existing products and the development of new products, including products, if any, to be developed under our recent industrial collaborations, may not proceed as planned, (vi) the risk that our PROCLEIX ULTRIO assay and our TIGRIS instrument for blood screening may not be approved by regulatory authorities or commercially available in the time frame we anticipate, or at all, (vii) we may not be able to compete effectively, (viii) we may not be able to maintain our current corporate collaborations and enter into new corporate collaborations or customer contracts, (ix) we are dependent on Chiron, Bayer and other third parties for the distribution of some of our products, (x) we are dependent on a small number of customers, contract manufacturers and single source suppliers of raw materials, (xi) changes in third-party reimbursement policies regarding our products could adversely affect sales of our products, (xii) changes in government regulation affecting our diagnostic products could harm our sales and increase our development costs, (xiii) the risk that our intellectual property may be infringed by third parties or invalidated, and (xiv) our involvement in patent and other intellectual property and commercial litigation could be expensive and could divert management's attention. The foregoing list sets forth some, but not all, of the factors that could affect our ability to achieve results described in any forward-looking statements. For additional information about risks and uncertainties we face and a discussion of our financial statements and footnotes, see documents we file with the SEC, including our most recent annual report on Form 10-K and all subsequent periodic reports. We assume no obligation and expressly disclaim any duty to update forward-looking statements to reflect events or circumstances after the date of this news release or to reflect the occurrence of subsequent events.

Contact:
    Michael Watts
    Sr. Director, Investor Relations and Corporate Communications
    858-410-8673



                            Gen-Probe Incorporated
                         Consolidated Balance Sheets
               (In thousands, except share and per share data)

                                                           December 31
                                                       2005           2004
    Assets
    Current assets:
    Cash and cash equivalents                        $32,328        $25,498
      Short-term investments                         187,960        168,328
      Trade accounts receivable, net of allowance
       for doubtful accounts of $790 and $664 at
       December 31, 2005 and 2004, respectively       31,930         21,990
      Accounts receivable - other                      1,924          3,136
      Inventories                                     36,342         27,308
      Deferred income taxes                           10,389          7,725
      Prepaid expenses                                10,768          8,517
      Other current assets                             4,184          5,447
    Total current assets                             315,825        267,949

    Property, plant and equipment, net               105,190         76,651
    Capitalized software                              20,952         23,466
    Goodwill                                          18,621         18,621
    License, manufacturing access fees and
     other assets                                     49,648         24,395
    Total assets                                    $510,236       $411,082

    Liabilities and stockholders' equity
    Current liabilities:
    Accounts payable                                 $14,029         $6,729
      Accrued salaries and employee benefits          14,910         11,912
      Other accrued expenses                           3,264          4,451
      Income tax payable                              13,192          1,188
      Deferred revenue                                 7,771          9,467
    Total current liabilities                         53,166         33,747

    Deferred income taxes                              5,124          9,187
    Deferred revenue                                   4,333          5,000
    Deferred rent                                        240            309

    Minority interest                                     --          1,810

    Commitments and contingencies

    Stockholders' equity:
    Preferred stock, $.0001 par value per share,
     20,000,000 shares authorized, none issued
     and outstanding                                      --             --
    Common stock, $.0001 par value per share;
     200,000,000 shares authorized, 51,137,541
     and 50,035,490 shares issued and outstanding
     at December 31, 2005 and 2004, respectively           5              5
    Additional paid-in capital                       281,907        248,767
    Deferred compensation                             (5,951)        (1,104)
    Accumulated other comprehensive (loss) income     (1,231)           807
    Retained earnings                                172,643        112,554
    Total stockholders' equity                       447,373        361,029
    Total liabilities and stockholders' equity      $510,236       $411,082



                            Gen-Probe Incorporated
                      Consolidated Statements of Income
                    (In thousands, except per share data)

                                  Three Months Ended        Years Ended
                                      December 31           December 31
                                    2005       2004       2005       2004
                                      (unaudited)
    Revenues:
      Product sales               $77,999    $58,483   $271,650   $222,560
      Collaborative research
       revenue                      6,485      7,852     25,843     27,122
      Royalty and license revenue   3,488      2,174      8,472     20,025
    Total revenues                 87,972     68,509    305,965    269,707

    Operating expenses:
      Cost of product sales        26,653     17,608     83,900     59,908
      Research and development     18,249     18,521     71,846     68,482
      Marketing and sales           8,780      7,233     31,145     27,191
      General and administrative    9,314      7,811     32,107     31,628
    Total operating expenses       62,996     51,173    218,998    187,209

    Income from operations         24,976     17,336     86,967     82,498
    Total other income, net         1,327        614      4,727      2,081
    Income before income taxes     26,303     17,950     91,694     84,579

    Income tax expense              9,548      5,974     31,605     30,004
    Net income                    $16,755    $11,976    $60,089    $54,575

    Net income per share:
      Basic                         $0.33      $0.24      $1.19      $1.10
      Diluted                       $0.32      $0.23      $1.15      $1.06

    Weighted average shares
     outstanding:
      Basic                        50,892     49,866     50,617     49,429
      Diluted                      52,619     51,705     52,445     51,403



                            Gen-Probe Incorporated
                    Consolidated Statements of Cash Flows
                                (In thousands)

                                                    Years Ended December 31
                                                      2005           2004
    Operating activities:
    Net income                                       $60,089        $54,575
    Adjustments to reconcile net income to net
     cash provided by operating activities:
      Depreciation and amortization                   22,606         18,239
      Stock compensation charges                         920          1,142
      Loss on disposal of property and equipment         399            377
      Stock option income tax benefits                 8,677         14,035
      Changes in assets and liabilities:
        Accounts receivable                           (8,937)        (6,774)
        Inventories                                   (9,048)       (13,621)
        Prepaid expenses                              (2,251)        (1,428)
        Other current assets                           1,263         (2,333)
        Accounts payable                               7,329         (2,535)
        Accrued salaries and employee benefits         2,998            242
        Other accrued expenses                        (1,089)        (2,329)
        Income tax payable                            12,053         (4,965)
        Deferred revenue                              (2,363)         2,119
        Deferred income taxes                         (6,717)         5,567
        Deferred rent                                    (69)           (14)
        Minority interest                                 --            (13)
    Net cash provided by operating activities         85,860         62,284

    Investing activities:
    Proceeds from sales and maturities of
     short-term investments                          116,907        159,301
    Purchases of short-term investments             (137,841)      (206,822)
    Cash paid for acquisition of minority interest
     in Molecular Light Technology Limited            (1,539)          (376)
    Purchases of property, plant and equipment       (45,386)       (26,021)
    Capitalization of intangible assets, including
     manufacturing and license fees                  (29,117)       (19,836)
    Other assets                                        (127)            42
    Net cash used in investing activities            (97,103)       (93,712)

    Financing activities:
    Proceeds from issuance of common stock            18,696         20,438
    Net cash provided by financing activities         18,696         20,438
    Effect of exchange rate changes on cash and
     cash equivalents                                   (623)           515
    Net increase (decrease) in cash and
     cash equivalents                                  6,830        (10,475)
    Cash and cash equivalents at the beginning
     of year                                          25,498         35,973
    Cash and cash equivalents at the end of year     $32,328        $25,498

    Supplemental disclosure of cash flow information:
    Cash paid for:
    Interest                                            $162            $34
    Income taxes                                     $16,807        $16,030

SOURCE Gen-Probe Incorporated

Michael Watts,
Sr. Director, Investor Relations and Corporate Communications of Gen-Probe Incorporated,
1-858-410-8673

http://www.prnewswire.com



Gen-Probe Incorporated
10210 Genetic Center Drive
San Diego, CA 92121

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